Comparative Evaluation of the Translocator Protein Radioligands ¹¹C-DPA-713, ¹⁸F-DPA-714, and ¹¹C-PK11195 in a Rat Model of Acute Neuroinflammation

Abstract

(18)F-DPA-714 appears to be an attractive alternative to (11)C-PK11195 because of its increased bioavailability in brain tissue and its reduced nonspecific binding. Moreover, its labeling with (18)F, the preferred PET isotope for radiopharmaceutical chemistry, favors its dissemination and wide clinical use. (18)F-DPA-714 will be further evaluated in longitudinal studies of neuroinflammatory conditions such as are encountered in stroke or neurodegenerative diseases.