Nonlinear Intestinal Absorption of 5-Hydroxytryptamine Receptor Antagonist Caused by Absorptive and Secretory Transporters

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

A pharmacokinetic analysis program (multi) for microcomputer.

Kiyoshi Yamaoka, Yusuke Tanigawara, Terumichi Nakagawa et al. · Journal of Pharmacobio-Dynamics · 1981 · 2.5K citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Cloning of a Serotonin Transporter Affected by Antidepressants

Beth J. Hoffman, Éva Mezey, Michael Brownstein · Science · 1991 · 611 citations

Medicine, Molecular Biology, Pharmacology +17

Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa

Allen R. Hilgers, Robert A. Conradi, Philip S. Burton · Pharmaceutical Research · 1990 · 582 citations

Pharmacy, Pharmaceutics, Pharmacology +15