<i>Kcne2</i> Deletion Creates a Multisystem Syndrome Predisposing to Sudden Cardiac Death

Abstract

Disruption of a single, widely expressed arrhythmia-susceptibility gene can generate a multisystem syndrome comprising manifold electric and systemic substrates and triggers of SCD. This paradigm is expected to apply to other arrhythmia-susceptibility genes, the majority of which encode ubiquitously expressed ion channel subunits or regulatory proteins.