Glibenclamide Is Superior to Decompressive Craniectomy in a Rat Model of Malignant Stroke

Abstract

In a rat model of severe ischemia/reperfusion, with reperfusion and treatment beginning 6 hours after onset of ischemia, glibenclamide is as effective as DC in preventing death from malignant cerebral edema but is superior to DC in preserving neurologic function and the integrity of watershed cortex and deep white matter.