Asymmetric Hydrogenation of Enol Phosphinates by Iridium Catalysts Having N,P Ligands

Abstract

[reaction: see text] Enol phosphinates, which are structural analogues of enol acetates, have for the first time been employed as substrates for Ir-catalyzed asymmetric hydrogenation. A number of enol phosphinates have been synthesized and reduced successfully with up to and above 99% ee.