Identification of the <i>Bcl</i>I polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids <i>in vivo</i> and body mass index

Abstract

We characterized a BclI-RFLP (restriction fragment length polymorphism) of the GR gene as a C/G polymorphism in intron 2 of which the G-allele was associated with hypersensitivity to glucocorticoids. This resulted in a lower BMI in older individuals in general, while our study in elderly males suggests that the lower BMI is probably due to a greater loss of lean mass during the ageing process.