On the role of endogenous opioid peptides: Failure of naloxone to influence shock escape threshold in the rat

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Purification and properties

Brian M. Cox, K E Opheim, H. Teschemacher et al. · Life Sciences · 1975 · 1.7K citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 981 citations

Medicine, Neuroscience, Pharmacology +14

BEHAVIORAL EFFECTS OF SEPARATE AND COMBINED ADMINISTRATION OF NALOXONE AND d-AMPHETAMINE

Stephen G. Holtzman · Journal of Pharmacology and Experimental Therapeutics · 1974 · 421 citations

Medicine, Behavioral Sciences, Pharmacology +15

An endogenous morphine-like factor in mammalian brain

Gavril W. Pasternak, Robert Goodman, Solomon H. Snyder · Life Sciences · 1975 · 393 citations

Life Sciences, Neurobiology, Neuroscience +14