Heat-Shock Protein 60-Reactive CD4 ⁺ CD28 ^null T Cells in Patients With Acute Coronary Syndromes

Abstract

We have shown that hHSP60 is an antigen recognized by CD4+CD28null T cells of ACS patients. Endothelial cells express hHSP60 either constitutively or under stress conditions. Circulating hHSP60-specific CD4+CD28null cells may, along other inflammatory mechanisms, contribute to vascular damage in these patients.