Three-dimensional reconstruction of in vivo blood vessels in human skin using phase-resolved optical Doppler tomography

Abstract

Phase-resolved optical Doppler tomography (ODT) has very high sensitivity while maintaining a fast axial scanning rate, making it possible to reconstruct blood flow in three dimensions. Here we demonstrate an ODT system that employed novel signal-processing techniques to remove aliasing effects and artifacts caused by lateral scanning and target movement. The results show that these techniques not only simplified ODT, but also improved lateral scanning speed. Using these signal-processing techniques, three-dimensional images of in vivo blood vessels in human skin were then reconstructed.