Sensors · 2011 · 133 citations · 52 references
EngineeringBioengineeringBiomedical EngineeringBiomedical OpticsOpticsPhotonicsMicroscale BiosensorsOptical BiosensingOptical BiosensorsOptical ResonatorsOptical SensingOptical SensorsFabricationFiltersMicro-optical SensorsMicroresonatorsNanophotonic CavitiesSpherical ResonatorsWhispering Gallery Mode BiosensorsWhispering-gallery-mode Resonators
Optical resonators play an ubiquitous role in modern optics. A particular class of optical resonators is constituted by spherical dielectric structures, where optical rays are total internal reflected. Due to minimal reflection losses and to potentially very low material absorption, these guided modes, known as whispering gallery modes, can confer the resonator an exceptionally high quality factor Q, leading to high energy density, narrow resonant-wavelength lines and a lengthy cavity ringdown. These attractive characteristics make these miniaturized optical resonators especially suited as laser cavities and resonant filters, but also as very sensitive sensors. First, a brief analysis is presented of the characteristics of microspherical resonators, of their fabrication methods, and of the light coupling techniques. Then, we attempt to overview some of the recent advances in the development of microspherical biosensors, underlining a number of important applications in the biomedical field.
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Protein detection by optical shift of a resonant microcavity
Frank Vollmer, Dieter Braun, Albert Libchaber et al. · Applied Physics Letters · 2002 · 902 citations