Aberrant Methylation and Deacetylation of <i>Deleted in Liver Cancer-1</i> Gene in Prostate Cancer: Potential Clinical Applications

Abstract

These results show that the transcriptional silencing of DLC-1 by two epigenetic mechanisms is common and may be involved in the pathogenesis of prostate carcinomas and benign prostatic hyperplasias and could have potential clinical application in the early detection and gene therapy of prostate cancer.