Proceedings of the National Academy of Sciences · 1974 · 231 citations · 16 references
PharmacyMedicinal ChemistryPharmacologyCancer PharmacologyDrug DesignMolecular OncologyCytotoxic ChemotherapyDna ChemistryDna StructureNucleic Acid Drug DesignOncology PharmacologyDna-drug InteractionsPyrimidine AnaloguesRational DesignReactivityTherapeutic Toxicity
The designing of DNA intercalating drugs with high DNA affinity in the series of ellipticine has led to a new antitumoral agent, 9-hydroxyellipticine, which has a high DNA affinity, a high activity on L 1210 mice leukemia, and a lack of toxicity at therapeutic dose. The possible correlations among chemical structure, DNA reactivity, and pharmacological activity of DNA intercalating drugs are discussed.
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Bruce N. Ames, William E. Durston, Edith F. Yamasaki et al. · Proceedings of the National Academy of Sciences · 1973 · 2.3K citations · Full text