Increased Interleukin‐18 in Patients With Juvenile Idiopathic Arthritis and Early Attachment Loss

Abstract

The findings of increased serum IL-18 and IL-1beta in patients with JIA accompanied by a similar subgingival microbiota suggest that the increased frequency of incipient attachment loss observed in these patients might be due to their altered systemic inflammatory response, making them more susceptible to periodontal disease.