PubMed · 2012 · 16 citations · 0 references
Life SciencesMolecular BiologyOncologyGene ExpressionGene Expression AnalysisMolecular OncologyCancer BiomarkersImmuno-oncology BiomarkersMolecular Tumor ProfilingTumor AntigensTumor MarkersTumor-associated AntigensBreast Cancer PrognosisClinicopathological CorrelationEstrogen Receptor StatusPrognostic BiomarkersProtein Expression BiomarkersTissue Microarray AnalysisTnm Staging SystemYes-associated Protein Signaling
BACKGROUND: The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. PATIENTS AND METHODS: YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. RESULTS: There were 29 patients (30.8%) with 1(+) expression, in YAP, 59 patients (62.8%) with 2(+) expression and 6 (6.4%) with 3(+) expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. CONCLUSION: YAP expression is not an independent prognostic factor in patients with breast cancer.