Concepedia

Synthesis of new imidazole derivatives as potential inhibitors of thromboxane synthetase

A. BANFI, Alberto Sala, P. A. SORESINETTI, Giovanni Russo

Journal of Heterocyclic Chemistry · 1990 · 12 citations · 20 references

DOI

Concepts

Abstract

Abstract The preparation of new imidazole derivatives containing a carboxylic moiety such as succinic, adipic or benzoic into the side chain, is reported starting from the suitable imidazole intermediates.

References

20

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3K citations · Full text

, , +21

: A selective inhibitor of thromboxane synthetase

Salvador Moncada, Stuart Bunting, Kevin Mullane et al. · Prostaglandins · 1977 · 305 citations

, , +5

Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets.

P Needleman, A Raz, James A. Ferrendelli et al. · Proceedings of the National Academy of Sciences · 1977 · 215 citations · Full text

, , +19

Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives

Kinji Iizuka, Kenji Akahane, Den-ichi Momose et al. · Journal of Medicinal Chemistry · 1981 · 157 citations · Full text

, , +11

Inhibition of human platelet thromboxane synthetase by 9,11-azoprosta-5,13-dienoic acid.

Robert R. Gorman, Gordon L. Bundy, David C. Peterson et al. · Proceedings of the National Academy of Sciences · 1977 · 112 citations · Full text

, , +17