Cancer Research · 2008 · 341 citations · 46 references
MedicineCancer BiologyOncologyGene ExpressionGene Expression AnalysisMolecular OncologyCancer BiomarkersCancer TranscriptomicsEsophageal CancerMicrorna BiologyMolecular Tumor ProfilingSquamous Cell CarcinomaClinicopathologic FeaturesMicroarray AnalysisMicrorna BiomarkersMicrorna Expression ProfilingMicrorna ProfilingMicrorna Prognostic MarkersMolecular Prognostic MarkersUnivariate Analysis
Esophageal cancer is the sixth leading cause of death from cancer and one of the least studied cancers worldwide. The global microRNA expression profile of esophageal cancer has not been reported previously. Here, for the first time, we have investigated expressed microRNAs in cryopreserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses identified seven microRNAs that could distinguish malignant esophageal cancer lesions from adjacent normal tissues. Some microRNAs could be correlated with the different clinicopathologic classifications. High expression of hsa-miR-103/107 correlated with poor survival by univariate analysis as well as by multivariate analysis. These results indicate that microRNA expression profiles are important diagnostic and prognostic markers of esophageal cancer, which might be analyzed simply using economical approaches such as reverse transcription-PCR.
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In silico prediction of protein-protein interactions in human macrophages
Oussema Souiai, Fatma Z. Guerfali, Slimane Ben Miled et al. · BMC Research Notes · 2014 · 11K citations · Full text
MicroRNA expression profiles classify human cancers
Jun Lü, Gad Getz, Eric A. Miska et al. · Nature · 2005 · 9.6K citations