Cascade Reactions Using LiAlH₄ and Grignard Reagents in the Presence of Water

Abstract

Divided we stand, together we fall: Incompatible reagents, such as water and LiAlH4, Grignard, or cuprate reagents, can be site-isolated on either side of a polydimethylsiloxane (PDMS) thimble (see scheme; SDS=sodium docecyl sulfate) for cascade reactions. The hydrophobic nature of the PDMS membrane prohibits polar molecules, such as water, from diffusing across the membrane. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z703002_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.