Designed supramolecular filamentous peptides: balance of nanostructure, cytotoxicity and antimicrobial activity

Abstract

This work demonstrates a design strategy to optimize antimicrobial peptides with an ideal balance of minimal cytotoxicity, enhanced stability, potent cell penetration and effective antimicrobial activity, which hold great promise for the treatment of intracellular microbial infections and potentially systemic anti-infective therapy.