Effect of an NK ₁ /NK ₂ Receptor Antagonist on Airway Responses and Inflammation to Allergen in Asthma

Abstract

Despite its demonstrated pharmacologic activity against inhaled NKA, multiple doses of AVE5883 increased the allergen-induced airway responses without affecting markers of airway hyperresponsiveness and airway inflammation. Our data question the prominent role of neurogenic inflammation in asthma and, consequently, the therapeutic potential of dual tachykinin antagonists.