Concepedia

Epiregulin as a Major Autocrine/Paracrine Factor Released From ERK- and p38MAPK-Activated Vascular Smooth Muscle Cells

Masanori Takahashi, Ken’ichiro Hayashi, Kenji Yoshida, Yasuyuki Ohkawa, Toshi Komurasaki, Akira Kitabatake, Akira Ogawa, Wataru Nishida, Masahiko Yano, Morito Monden,

Circulation · 2003 · 75 citations · 10 references

DOI

Abstract

Epiregulin is released from VSMCs primed by atherogenic factors and acts as a major autocrine/paracrine factor for VSMC dedifferentiation. It may be involved in the progression of vascular remodeling such as atherosclerosis.

References

10

Epiregulin

Toshiaki Isobe, Tuneo Okuyama, Hitoshi Toyoda et al. · Journal of Biological Chemistry · 1995 · 267 citations · Full text

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Expressional regulation of smooth muscle cell-specific genes in association with phenotypic modulation

Kenji Sobue, Ken’ichiro Hayashi, Wataru Nishida · Molecular and Cellular Biochemistry · 1999 · 239 citations

Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids

Ken’ichiro Hayashi, Masanori Takahashi, Wataru Nishida et al. · Circulation Research · 2001 · 192 citations

Changes in the Balance of Phosphoinositide 3-Kinase/Protein Kinase B (Akt) and the Mitogen-activated Protein Kinases (ERK/p38MAPK) Determine a Phenotype of Visceral and Vascular Smooth Muscle Cells

Ken’ichiro Hayashi, Masanori Takahashi, Kazuhiro Kimura et al. · The Journal of Cell Biology · 1999 · 190 citations · Full text

Differentiated Phenotype of Smooth Muscle Cells Depends on Signaling Pathways through Insulin-like Growth Factors and Phosphatidylinositol 3-Kinase

Ken’ichiro Hayashi, Hiroshi Saga, Yoshihiro Chimori et al. · Journal of Biological Chemistry · 1998 · 183 citations · Full text