Correlated Expression of<i>CD47</i>and<i>SIRPA</i>in Bone Marrow and in Peripheral Blood Predicts Recurrence in Breast Cancer Patients

Abstract

This is one of the first studies to show that a host factor in bone marrow confers prognostic importance. CD47 is an important biomarker in breast cancer, and functions as a prognostic factor for DFS. Moreover, we suggest that the poor prognosis of breast cancer patients with high expression of CD47 is due to an active CD47/SIRPA signaling pathway in circulating cells.