Total Synthesis and Determination of the Absolute Configuration of (+)‐Intricatetraol

Abstract

A victory for synthesis: The total synthesis of the marine triterpene polyether (+)-intricatetraol (1) has revealed its absolute configuration, which could not be determined even by spectroscopic methods. The approach features the enantioselective construction of the unique vicinal bromochloro functionality and an efficient olefin-metathesis strategy that takes the C2 symmetry of the target into consideration. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603806_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.