Frequency-Dependent Reciprocal Modulation of Verbal Fluency and Motor Functions in Subthalamic Deep Brain Stimulation

Abstract

The study provides evidence of a beneficial effect of low-frequency (10 Hz) STN DBS on VF, which may be caused by activating neural pathways projecting to the frontal cortex. In addition, the study reproduces the negative effect of therapeutic high-frequency STN DBS on VF. The study results provide evidence for a frequency-dependent modulation of cognitive circuits involving the STN.