Preparation and Asymmetric Hydrogenation of β‐Aryl‐Substituted β‐Acylaminoacrylates

Abstract

The Rh-catalyzed asymmetric hydrogenation of β-aryl-substituted (E)-β-acylaminoacrylates, which were isolated for the first time, with, for example [Rh{(R,R)-(Et-FerroTANE)}(nbd)]+ as catalyst (see picture) proceeds under very mild conditions (25 °C, normal pressure) and high substrate/catalyst ratios with very good enantioselectivity (Et-FerroTANE=(+)-1,1′-bis(2,4-diethylphosphyltane)ferrocene, nbd=3,5-norbornadiene). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z50265_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.