Preparation and Asymmetric Hydrogenation of β‐Aryl‐Substituted β‐Acylaminoacrylates

Abstract

The Rh-catalyzed asymmetric hydrogenation of β-aryl-substituted (E)-β-acylaminoacrylates, which were isolated for the first time, with, for example [Rh{(R,R)-(Et-FerroTANE)}(nbd)]+ as catalyst (see picture) proceeds under very mild conditions (25 °C, normal pressure) and high substrate/catalyst ratios with very good enantioselectivity (Et-FerroTANE=(+)-1,1′-bis(2,4-diethylphosphyltane)ferrocene, nbd=3,5-norbornadiene).