Somatodendritic 5-hydroxytryptamine_1A(5-HT_1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone

Abstract

These findings are consistent with an increase in the functional status of somatodendritic, but not postsynaptic, 5-HT1A autoreceptors, in medication-free depressed patients in line with hypotheses based on genetic data. This increase in functional status would be hypothesized to lead to an increase in serotonergic negative feedback, and hence decreased release of 5-HT at raphé projection sites, in depressed patients.