P-glycoprotein Binding and Modulation of the Multidrug-Resistant Phenotype by Estramustine

Abstract

It is apparent from the P-glycoprotein data that estramustine interacts with this efflux pump, altering intracellular drug accumulation. Overall, the nonempiric basis for including estramustine in clinical protocols that contain other multidrug-resistant drugs is strengthened by the present data.