An Efficient Diastereoselective Route to Differentially Protected <i>anti</i>-4-Amino-1-alken-3-ols

Abstract

Zinc-promoted hydroxyallylation of alpha-amidoalkyl arylsulfones 4 using 3-bromo-propenyl methyl carbonate 5 proceeds smoothly in DMF at room temperature to afford high yields of differentially protected anti-1,2-amino alcohols 6.