Chemical Proteomics Discloses Petrosapongiolide M, an Antiinflammatory Marine Sesterterpene, as a Proteasome Inhibitor

Abstract

Gone fishing: Petrosaspongiolide M (PM), a marine γ-hydroxybutenolide sesterterpenoid, was efficiently immobilized on a solid support to selectively bind its macromolecular targets in a macrophage cell lysate. The proteasome machinery was identified as its most important partner. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.