Publication | Closed Access
Synthesis of a Nine‐Membered Cyclic Analogue of the Neocarzinostatin Chromophore and Its DNA‐Cleaving Activity
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Citations
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References
1993
Year
Combinatorial ChemistryBioorganic ChemistryMolecular BiologyOrganic ChemistryDiyne 1Heterocycle ChemistryChemical BiologyPharmaceutical ChemistryMedicinal ChemistryNine‐membered Cyclic AnalogueDna‐cleaving ActivityBiochemistryOligonucleotideNeocarzinostatin ChromophoreNatural Product SynthesisHeterocyclicNatural SciencesStable Analogue 1Drug Discovery
The highly strained but relatively stable analogue 1 of the neocarzinostatin chromophore was synthesized by a transannular [2,3]-Wittig rearrangement and characterized. Diyne 1 is the first analogue of this type with DNA cleaving activity and may thus have potential as an anticancer agent.
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