Expeditious Synthesis of Tetrasubstituted Helical Alkenes by a Cascade of Palladium‐Catalyzed CH Activations

Abstract

Twisted molecules: A modular approach for the synthesis of tetrasubstituted helical alkenes by a palladium-catalyzed norbornene-mediated domino reaction is presented. This intermolecular domino process allows the formation of three C-C bonds in one operation through a C-H activation/carbopalladation/C-H activation sequence.