Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart disease

Abstract

With the present study we can show for the first time that the embryonal MTHFR 677TT genotype is significantly associated with the development of structural congenital heart malformations during early pregnancy. It remains to be clarified, whether this genotype is at least a risk marker or a risk factor for structural congenital heart malformations.