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Oxazolidin-2-one Ring, a Popular Framework in Synthetic Organic Chemistry: Part 1. The Construction of the Oxazolidin-2-one Ring
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2007
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Organic ChemistryChemistryHeterocycle ChemistrySynthetic Organic ChemistryMedicinal ChemistryDiversity Oriented SynthesisStereoselective Synthesis1,3-Oxazolidin-2-one NucleusCurtius- RearrangementDiversity-oriented SynthesisPopular FrameworkPharmacologyBiomolecular EngineeringHeterocyclicNatural SciencesMedicineSynthetic ChemistryOxazolidin-2-one RingDrug Discovery
The 1,3-oxazolidin-2-one nucleus is a popular heterocycle framework in synthetic organic chemistry, as well as in medicinal chemistry. This paper deals with the huge number of synthetic approaches addressed to the construction of this five-member ring, with a particular care for the mechanistic and stereochemical outcome. Keywords: 1,3-Oxazolidin-2-one, cyclocarbamation reactions, 1,2-aminoalcohol, epoxides and aziridines, amino-acids, Curtius- rearrangement