Publication | Closed Access
Synthesis of a TRPV1 Receptor Antagonist
45
Citations
17
References
2009
Year
Combinatorial ChemistryMedicinal ChemistryBiochemistryTrpv1 Receptor AntagonistFive-step SynthesisBenzyl Urea 9Natural SciencesMedicineAntiviral Drug DevelopmentUrea 1Heterocycle ChemistryPharmacologyPharmaceutical ChemistrySynthetic ChemistryDrug Discovery
A five-step synthesis of a TRPV1 receptor antagonist 1 is described. The key step involves a novel palladium-catalyzed amidation reaction of 4-chloro-1-methylindazole 8 with the benzyl urea 9 to form the unsymmetrically substituted urea 1.
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