Concepedia

Synthesis of a TRPV1 Receptor Antagonist

Su Yu, Anthony R. Haight, Brian Kotecki, Lei Wang, K. A. LUKIN, David R. Hill

The Journal of Organic Chemistry · 2009 · 46 citations · 17 references

DOI

Concepts

Abstract

A five-step synthesis of a TRPV1 receptor antagonist 1 is described. The key step involves a novel palladium-catalyzed amidation reaction of 4-chloro-1-methylindazole 8 with the benzyl urea 9 to form the unsymmetrically substituted urea 1.

References

17

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UNSYMMETRICAL UREAS. SYNTHETIC METHODOLOGIES AND APPLICATION IN DRUG DESIGN

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