Arginine-16 2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol

Abstract

The arginine-16 genotype of ADRB2 predisposes to exacerbations in asthmatic children and young adults, particularly in those exposed to regular salmeterol. This may be explained by genotype selective salmeterol induced downregulation and impaired receptor coupling, and associated subsensitivity of the response.