General Characteristics of Sympathetic Activity in Human Skin Nerves

TLDR

Efferent sympathetic bursts were recorded in awake adults by inserting microelectrodes into skin nerve fascicles, and the signals were eliminated by ganglion blockers and proximal lidocaine blocks. Sympathetic bursts in skin nerves triggered local vasoconstriction but were not pulse‑synchronous or baroreflex‑controlled, showing independence from blood‑pressure changes and only a weak coupling to respiration.

Abstract

Abstract Synchronized bursts of efferent sympathetic impulses, appearing either spontaneously or triggered by various peripheral stimuli, were recorded with microelectrodes inserted percutaneously into skin nerve fascicles in alert, adult subjects. The signals were abolished by sympathetic ganglion blocking agents and by Lidocaine nerve blocks proximal to the recording site. Many of the sympathetic discharges were succeeded by skin resistance changes and plethysmographic vasoconstrictor responses within the innervation zone of the fascicle impaled. The sympathetic activity was not pulse synchronous as in muscle nerves and the spontaneous sympathetic volleys occurred largely independently of spontaneous blood pressure variations, indicating a relative lack of baroreflex control of the vasoconstrictor outflow to the skin. A loose coupling was observed, however, between the resting respiratory rhythm and the spontaneous sympathetic bursts in the skin nerves.