Expression of Erythropoietin Receptor and<i>In vitro</i>Functional Effects of Epoetins in B-Cell Malignancies

Abstract

EPO-R gene is frequently expressed in lymphoid malignancies and normal B and T cells. However, there was no surface protein expression and no epoetin-induced in vitro stimulation of tumor B cells, indicating that epoetin therapy in vivo is likely to be safe in patients with lymphoid malignancies.