Journal of the European Academy of Dermatology and Venereology · 2011 · 87 citations · 33 references
MedicineDermatologySurgeryOphthalmic SurgeryPediatric DermatologyPediatric PharmacotherapyAntianginal TherapyLaser SurgeryPediatric Dermatological TherapiesPropranolol Therapy
Because of their spontaneous involution, most infantile haemangiomas (IH) do not require therapeutic intervention. However, in 10 to 15% of cases such as segmental and multifocal IH, locations in the periocular, airway and perineal areas, or complications of ulceration, treatment is necessary. Moreover, the risk of permanent scarring and disfigurement associated with IH, even if involution is complete, has been increasingly recognized as a rationale for treatment. Treatments for IH currently include topical, intralesional, systemic therapies, laser and surgical modalities depending on the clinical scenario. However, clinicians must carefully weigh the risks and benefits for each treatment. Recently, the efficacy of propranolol, a non-cardioselective beta-blocker, was reported and has been revolutionary in the management of IH.
33
Propranolol for Severe Infantile Hemangiomas: Follow-Up Report
Véronique Sans, Eric Dumas de la Roque, Jérôme Berge et al. · PEDIATRICS · 2009 · 570 citations