Evidence for Increased Serum Glutamic Oxalacetic Transaminase (SGO-T) Activity Following Graded Myocardial Infarcts in Dogs

Abstract

Elevation in serum concentration of the enzyme, glutamic oxalacetic transaminase, (SGO-T), is an accurate index of myocardial infarction in dogs. The enzyme rises in a rough proportion to the extent of myocardial necrosis. The test is a sensitive guide to myocardial injury. Infarcts less than 1 Gm. in weight result in a significant alteration in serum concentration of the enzyme. Concentrations of the enzyme in infarcted muscle are markedly lower than in normal muscle, suggesting that seepage through damaged cells causes the rise in serum concentration. Experimental and clinical myocardial injury result in similar abnormalities.