Thalidomide attenuates nitric oxide‐driven angiogenesis by interacting with soluble guanylyl cyclase

Abstract

Our results showed that thalidomide interacted with sGC, suppressing cGMP levels in endothelial cells, thus exerting its anti-angiogenic effects. These results could lead to the formulation of thalidomide-based drugs to curb angiogenesis by targeting sGC.