Anesthesiology · 1972 · 256 citations · 0 references
MedicinePharmacokineticsPharmacologyAnesthesiaPharmacodynamicsBrain Energy MetabolismCerebral Blood FlowCerebrovascular PhysiologyPharmacokinetics In SurgeryAnaesthetic Effects On Cerebral PhysiologyAnesthetic Effects On Cerebral Blood FlowCerebral Blood Flow AlterationsCerebral Blood Flow EffectsCirculationKetamine PharmacologyKetamine TherapyKetamine Treatment
The effects of ketamine on cerebral circulation and metabolism were studied in ten healthy patients before elective surgical operations. With intravenous administration of ketamine in two increments (3 mg/kg total), cerebral blood flow increased from a control value of 47 to 76 ml/100 g/min and cere