In Situ Generation of PhI⁺CF₃ and Transition‐Metal‐Free Oxidative sp² CH Trifluoromethylation

Abstract

These things are sent to tri us: The introduction of CF3 units into organic molecules is important and requires the development of convenient trifluoromethylating reagents. Here, PhI+CF3, an acyclic electrophilic “CF3+” species, is described, including its in situ generation from TMSCF3, PhI(OAc)2, and KF and its direct applications in sp2 CH trifluoromethylations under mild transition-metal-free conditions (see scheme). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.