The Journal of Antibiotics · 1983 · 10 citations · 3 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryMedical MicrobiologyAntibiotic ResistanceBeta-lactam ResistanceBeta-lactamase InhibitorsMacrolide AntibioticsSpectrum Of Beta-lactam Antibioticsβ-Lactam Antibiotics
Two new carbapenem antibiotics, carpetimycins C and D have been isolated from the culture broth of Streptomyces sp. KC-6643, which produced carpetimycins A and B. The structures of carpetimycins C and D have been determined to be (5R,6R)-3-[2-acetamidoethyl-(R)-sulfinyl]-6-(1-hydroxy-1-methylethyl) -7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and (5R,6R)-3-[2-acetamidoethyl-(R)-sulfinyl]-6-(1-hydroxysulfonyloxy-1 -methylethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, respectively. Studies on the fermentation, isolation and physico-chemical properties of these antibiotics are also described.
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CARPETIMYCINS A AND B, NEW β-LACTAM ANTIBIOTICS
MASAHITO NAKAYAMA, Akio Iwasaki, Shigeru Kimura et al. · The Journal of Antibiotics · 1980 · 63 citations · Full text
Structures and absolute configurations of carpetimycins A and B.
MASAHITO NAKAYAMA, Shigeru Kimura, Sohei Tanabe et al. · The Journal of Antibiotics · 1981 · 33 citations · Full text