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First total synthesis of modiolide A, based on the whole-cell yeast-catalyzed asymmetric reduction of a propargyl ketone

BiosynthesisPropargyl KetoneEngineeringBiochemistryEnantioselective SynthesisNatural SciencesFirst Total SynthesisMolecular BiologyOrganic ChemistryNatural Product SynthesisAsymmetric CatalysisSynthetic ChemistryModiolide A