Antioxidant Intervention Attenuates Myocardial Neovascularization in Hypercholesterolemia

Abstract

Changes in myocardial microvascular architecture invoked by HC are accompanied by increases in HIF-1alpha and VEGF expression and attenuated by antioxidant intervention. This underscores a role of increased oxidative stress in modulating myocardial microvascular architecture in early atherogenesis.