Nucleic Acid with Guanidinium Modification Exhibits Efficient Cellular Uptake

Abstract

Quick on the uptake: A 20-mer DNA oligomer modified with 5-[(6-guanidiniohexylcarbamoyl)methyl]-2′-deoxyuridine (Tg) shows efficient cellular uptake (blue arrow) in HeLa cells without any other reagents. The fluorescence microscopy image reveals FAM-labeled DNA oligomer (green) and stained nuclei (blue). FAM=6-carboxyfluorescein. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500904_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.