Concepedia

Formation and metabolism of N-nitrosamines

K Rostkowska, Krzysztof Zwierz, Andrzej Różański, J Moniuszko-Jakoniuk, Alicja Roszczenko

Polish Journal of Environmental Studies · 1998 · 55 citations · 5 references

Concepts

Abstract

The formation of nitrosamines and reactions of the first and second phase of their biotransformations were reviewed.

References

5

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of <i>N</i>-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

Hiroshi Yamazaki, Yukiharu Inui, Chul‐Ho Yun et al. · Carcinogenesis · 1992 · 399 citations

, , +13

Esophageal and hepatic microsomal metabolism of N-nitrosomethylbenzylamine and N-nitrosodimethylamine in the rat.

George E. Labuc, Michael C. Archer · PubMed · 1982 · 71 citations

, , +13

<i>In vivo</i> and <i>in vitro</i> genotoxicity of several <i>N</i>-nitrosamines in extrahepatic tissues of the rat

S. Brendler, Anna Tompa, K Hutter et al. · Carcinogenesis · 1992 · 39 citations

, , +16

Metabolism of N-nitrosomethyl-n-amylamine by microsomes from human and rat esophagus.

Qin Huang, Gary D. Stoner, James Resau et al. · PubMed · 1992 · 19 citations

, , +13

The migration of tobacco-specific nitrosamines into the saliva of chewers of nicotine-containing chewing gum

B G Österdahl · Food and Chemical Toxicology · 1990 · 11 citations

, , +4