Prenylated Flavanones from<i>Derris laxiflora</i>

Abstract

Abstract A new prenylated flavanone 1 [laxiflorin (2S)-5,7,3′,4′-tetrahydroxy-6-(β-hydroxyethyl)-8-(γ,γ-dimethylallyl)flavanone] and four known flavanones (6,8-diprenyleriodictyol, hiravanone, senegalensein and lupinifolin) were isolated from the leaves and twigs of Derris laxiflora. Laxiflorin with a β-hydroxyethyl group at C-6 exhibited significant inhibitory activity against protein-tyrosine kinase.