Concepedia

Mitochondria Oxidative Stress, Connexin43 Remodeling, and Sudden Arrhythmic Death

Ali A. Sovari, Cody A Rutledge, Euy‐Myoung Jeong, Elena Dolmatova, Divya Arasu, Hong Liu, Nooshin Vahdani, Lianzhi Gu, Shadi Zandieh, Lei Xiao,

Circulation Arrhythmia and Electrophysiology · 2013 · 115 citations · 39 references

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Abstract

Mitochondrial oxidative stress plays a central role in angiotensin II-induced gap junction remodeling and arrhythmia. Mitochondria-targeted antioxidants may be effective antiarrhythmic drugs in cases of renin-angiotensin system activation.

References

39

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

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Characterization of three inhibitors of endothelial nitric oxide synthase <i>in vitro</i> and <i>in vivo</i>

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A Clinical Trial of the Angiotensin-Converting–Enzyme Inhibitor Trandolapril in Patients with Left Ventricular Dysfunction after Myocardial Infarction

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Vitamins E and C in the Prevention of Cardiovascular Disease in Men

Howard D. Sesso · JAMA · 2008 · 896 citations · Full text

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

Junya Kuroda, Tetsuro Ago, Shouji Matsushima et al. · Proceedings of the National Academy of Sciences · 2010 · 764 citations · Full text