Gold‐Catalyzed <i>endo</i>‐Cyclizations of 1,4‐Diynes to Seven‐Membered Ring Heterocycles

Abstract

endo-Rule for gold: A highly endo-selective gold-catalyzed cycloisomerization of 1,4-diynes was developed. By employing electron-rich phosphines and N-heterocyclic carbenes as ligands, a number of 1,4-diynes could be cyclized in a desymmetrizing fashion to form dihydrodioxepines and enantiomerically enriched tetrahydrooxazepines (see scheme). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.