CaMKII-Dependent Diastolic SR Ca ²⁺ Leak and Elevated Diastolic Ca ²⁺ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation

Abstract

Increased CaMKII-dependent phosphorylation of RyR2 leads to increased SR Ca(2+) leak in human AF, causing elevated cytosolic Ca(2+) levels, thereby providing a potential arrhythmogenic substrate that could trigger or maintain AF.